ROS Enhances CXCR4-mediated Functions through Inactivation
Deletion of PTEN alleles in a mouse model accelerates the progression of small cell lung carcinoma, and also accelerates another lung cancer type, adenocarcinoma.
Inactivation of the PTEN Tumor Suppressor Gene is
Read PTEN function in normal and neoplastic growth, inactivation of Pten in the mouse prostate Pten and p27KIP1 cooperate in prostate cancer tumor
PTEN - Cancer Genetics Web
The concept that vegetables and fruits are relevant sources of cancer-preventive substances is strongly supported by population studies. Among others, cruciferous vegetables like broccoli, cabbage, cauliflower and Brussels sprouts are thought to affect the development of various types of cancers and especially prostate tumors.
Genomic Deletion of PTEN Is Associated with Tumor
Inactivation of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is heavily implicated in the tumorigenesis of prostate cancer. Conversely, the upregulation of the chemokine (CXC) receptor 4 (CXCR4) is associated with prostate cancer progression and metastasis
Both p110α and p110β isoforms of PI3K can modulate
. . in prostate cancer cells consistent with a previous finding that heterozygous PTEN inactivation induced uterine cancer was unresponsive to
PTEN genomic deletion predicts prostate- BMC Cancer
Genetic alterations in the PTEN gene are frequent in prostate cancers. In normal cells, PTEN acts as a tumor suppressor, controlling unregulated growth.
Determining Risk of Biochemical Recurrence in Prostate
National Academy of Sciences. These cancer cell lines represent the major cancer types with a high frequency of PTEN inactivation, namely prostate cancer
KLF5 inhibits angiogenesis in PTEN-deficient prostate
Haploinsufficiency is common in prostate cancer and homozygous loss of PTEN is Advances in Urology human prostate cancer. Biallelic inactivation of
Broccoli, PTEN deletion and prostate cancer: where is
We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the